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Diversity and response in immune repertoires

Publié le 29 avril 2019 Mis à jour le 29 avril 2019

3rd of May 2019 3-4 pm (IB)² seminar  - Solvay room

Thierry Mora (ENS, Paris)

The diversity of repertoires of B-cell and T-cell receptors is generated by a stochastic process of gene rearrangement called VDJ recombination, and is later sculpted by selection, clonal proliferation, and somatic hypermutations. I will show how these processes can be learned quantitatively from high-throughput repertoire sequencing data. The resulting models can then be used to estimate the diversity of repertoires and their overlap between individuals, to identify condition-specific immune receptors from patient cohort data, and to detect signatures of immune responses in single patients, opening the way for novel sequencing-based diagnostic and prognostic tools.

Date(s)
Le 3 mai 2019